This news article was originally written in Spanish. It has been automatically translated for your convenience. Reasonable efforts have been made to provide an accurate translation, however, no automated translation is perfect nor is it intended to replace a human translator. The original article in Spanish can be viewed at La unión entre azúcares y el ADN en cuadrúplex permite el diseño de nuevos fármacos anticancerígenos
The union between sugars and the DNA in cuadrúplex allows the design of new drugs anticancerígenos
05/03/2013
5 March 2013
The strengths that use the molecules to join ones to others have a fundamental paper in the effectiveness of the drugs, that use these same strengths to anchor to key molecules in the development of illnesses. An investigation of the Upper Council of Scientific Investigations (CSIC) reveals new mechanisms of union to the DNA in cuádruplex that could serve to develop new drugs anticancerígenos.
This type of genetic material is used to to locate in the extremes of the telómeros –terminal regions of the chromosomes–. Unlike the chains of DNA of double propeller, the genetic material in cuádruplex forms structures of games apilados of units of four bases of guanine (one of the four types of nitrogenous bases that compose the DNA). Recently it has been showed that distinct oncogenes present similar structures.
The investigation of the CSIC, that has been published in the magazine Chemicals an European Journal, reveals that distinct types of sugars interact of favourable way with the tétrada of guanines of the DNA in cuádruplex. For this use molecular interactions that, up to now, had not associated to this type of structures.
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Consejo Superior de Investigaciones Científicas
